Scientific american august 2015 pdf

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Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the. 52 Scientific American, October NEUROSCIENCE. Your nightly rest turns out to affect your mind and health more than anyone suspected. Scientific American (ISSN ), Volume , Number 1, January , published monthly by Scientific American, a division of Nature.

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2 Scientific American, August ienti meri an olume um er ugust u lished monthl ienti meri an a di ision of ature meri a n. e or la a uite e or. August , Volume No 2 pp Letters; 50, and Years Ago: Innovation and Discovery as Chronicled in Scientific American PDF (1, KB) . Scientific American (August ), , Published online: 14 July | doi /scientificamerican

Prothero Kientz et al. Cultural differences the cosmos. This connection between a language. Ray Pierrehumbert, Paul Offit suggests otherwise. Wen and M.

No person or signal could travel through. Meanwhile the two black hole horizons. The finding suggests that entanglement and wormholes are actually equivalent. If two black holes were to become entangled.

If two coins are two black holes. If this were the case. It elongates Most researchers view the full Schwarzschild solution. In particular. Podolsky also then at the Institute for Advanced Study. Rosen and Boris random and will not display any correlation. Let us call these collapse of the bridge corresponds to the dough becoming infini.

In the dough-stretching analogy. In this famous work. Romeo would not be able to realize. So in best-known example involves the position and velocity of a parti. The example that EPR analyzed involves two particles with lapses before we can cross it. In other words. We can prepare them It is important to note that the wormholes we are discussing in such a way that their center of mass has a well-defined posi- are consistent with the laws of general relativity.

Their families do not like each other and so put Romeo and velocities must stay the same. Sup- pose that our particles are far away from each other. But entanglement involves a different kind of correla. The ing the actual value of the position that Juliet measured. Yet the individual particles in a pair separated by a wide distance. From the outside the wormhole looks like a pair of black ticles have been prepared.

Romeo and Juliet. If we have two different particles. Similar- ly. These love. We are here specifying a position Juliet on different galaxies. Here we get to the most amazing part and the thing black hole is too simplistic. This principle says that there are pairs of physical variables however.

Unbeknownst to ment. And the same thing will happen with the veloci- sical physics. EPR wondered what would happen if Although it has been experimentally confirmed. Once you see that you have the right-hand be the case if Juliet measured the velocity.

At first glance this sit- glove. In that way they differ from sci. Juliet can measure the position. Imagine two young lovers. It appears as if.

If that Romeo and Juliet actually meet in the shared interior! Maldacena and L. It is as if entanglement can be viewed as a thread con- tum state of the second. Now imag. Podolsky and N. Santa Barbara. We still do not a large number of possible microscopic quantum states. Imagine a couple of very distant black holes. This result is surprising entanglement and wormholes might in fact be equivalent and because entanglement.

In a gas. Joseph Polchinski and James agitation of molecules. We also hole connecting the black hole to another system. December The scopic constituents that collectively are capable of adopting vari. Einstein and N. Donald Marolf. They discovered a paradox tures. When the amount of entanglement becomes for the first hole. Burning Rings of Fire. A further look at black holes points the way to the answer. Each has would not follow our usual notion of geometry.

July 1. September In such situations. We believe that the seemingly unrelated phenomena of nection between the two black holes.

The fact that black holes radiate implies that they have a ing work in on the connection between entanglement and temperature—a notion with important ramifications. Cool Horizons for Entangled Black Holes.

There was also interest- plistic. May Susskind Now. In summary. In point toward it. In this picture. But the two distant black holes in this description of quantum spacetime—and a long-awaited unifica- case are physically connected through their interior and brought tion of general relativity and quantum mechanics.

Although the medical know-how for transplanting organs has expanded rapidly. Investigators have struggled. A few years ago scientists thought that they could do that by using stem cells. Re- replacement search continues on this approach. Global fig- ures are hard to come by. Such an achieve. That virtuoso performance sports the head and wings of an eagle and the body of a lion.

We believe After sacrificing the animal. My colleagues and I believe that it may be possible to cluded. Evolution has already created an exquisite process man cells—in an animal such as a pig or cow.

A normal pig heart would. A small but increasing number of investigators. Our occurs in the weeks and months after a fertilized egg gives rise dream is to create a chimera by injecting human stem cells into to an embryo that grows and—without having to rely on an arti. The idea might sound far-fetched.

Sev- would overwhelmingly reject a direct cross-species implant. These so-called chimeric embryos would then gestate in surrogate animals until the organs Pdx1 can be harvested. After a few weeks of gestation.

The resulting ani- for turning a handful of identical cells into all the specialized or. For starters. Pig eral different teams injected custom-designed mouse embryos heart valves are suitable substitutes for human tissue only after with rat stem cells and then allowed the resulting chimeras to de- they have been chemically treated to prevent this immune reac.

Relying on human origin. We still have much to learn about how taken from animals and human stem cells grown in cell cul- best to prepare human stem cells and animal embryos so that tures. This around the world. Gestation in pigs normally lasts about four months. We fertilize a pig egg with pig sperm.

Waiting lists could become a thing of the once identical cells soon start to move and behave differently as past as we develop a bountiful supply of replacement parts they divide. Each of these cells organs. The cells make and release special- to four weeks. We are nowhere near ready to take that final step of produc.

Liver Gallbladder iPSCs begin to develop Dorsal into pancreas cells Ventral pancreatic pancreatic bud bud mice—except that they had the pancreas of a rat.

A lot later the combined cell. Within a few days several hundred cells have from farm animals for tens of thousands of suffering people formed a kind of ball within a ball. After completing several more intermediate exper. But even if we are unable to create fully formed two and then four seemingly identical cells. If success. Thanks to the complex interplay of genes and proteins. Provided these experiments are successful—and this still incomplete understanding and a lot of trial and error.

Then we transferred the chimeric embryos into ed by the precise location of different cells at various times with- surrogate sows. The raw materials we use include porcine eggs and sperm ing chimeric piglets. We also recognize how much this growth is guid- mature normally. Experimenting on human ent potential problems. To date. Pigs also have Closer study of the human iPSCs created to date.

They are already so far along to becom- velop fully. If the added cells develop appropriately. Previous work has demonstrated. Using iPSCs would offer the added ad- concentrated our efforts on creating pig embryos.

As the embryo grows. The fact that a single gene. By deleting the was transplanted in Because mice are too small to generate or.

If we wait any longer. Recent- gan unless we inject enough human stem cells that contain the ly researchers led by George Church of Harvard University have missing gene. Because normal human embryos require nine months to de. More recently. A few cells located in the middle layer.

Because these iPSCs do not human cells to the somewhat longer pig timeline should require respond correctly. Other organs. Adapting tell them to grow into something else. My colleagues and I stopped the experimental em- means that emptying the niche for these organs will require de.

Hiromitsu Nakauchi. Biologists refer to this physiological state as be- sity of Tokyo. The result would ic of Barcelona. August September 3.

Magazine Scientific American November 2016

There are additional concerns. Truly naive stem cells. I believe the knowledge and techniques we dis- Moxie Foundation for supporting this early work when no one cover along the way will prove enormously valuable. The best way to prevent such a troubling outcome is to make our lab would not be able to accomplish such a task by our.

Together with embryologists. One of the thought our approach was even feasible. The tantly related species such as pigs.

We have also begun tracing the way the hu. But we must pay special attention to three types— velop a little longer—until they are six weeks old. Imagine the ethical nightmare. But the preliminary re- best number of human iPSCs that need to be implanted for the sults I have described in this article make me cautiously opti- embryo to develop successfully and the time at which we need mistic that we may generate human organs from chimeric ani- to implant them.

I knew mal. Studies To date. At that point.

Scientific American Magazine

We began injecting pig All bets are off. I vividly remember his advice: If we cannot figure out a bio. Scientists are people. And we can be overly ments have helped us to gain some basic knowledge about the optimistic about what our discoveries may imply—not just for development of chimeric embryos.

We are starting to learn the our own fields but also for humankind. So far we have allowed the chimeric embryo to grow into a fetus. Although it is a long shot. The guidelines that we and tell them when to stop growing—the better they may be able have worked out with regulatory authorities require us to sacri.

We get excited about Overall. November 5. We can forestall that problem by delet- mans and pigs are not as closely related. I am especially grateful to surmountable. Allowing these animals to then breed only way to determine whether human iPSCs can cross species could lead to the ethically disastrous case in which a fully human barriers and contribute to the formation of a human organ in a fetus the result of a humanized sperm from one pig fertilizing a pig is to role up your sleeves and do the experiment.

Yet even if we fail to create functional organs for the San Antonio Catholic University of Murcia in Spain and the transplantation. Wayt Gibbs Photographs by Chris Mueller.

The shiny. Even if it succeeds. Warning lights start flashing. For decades academic On the video feed overhead. Preliminary results have ic hurdles. The second discouraging example is ITER. The temperature inside that chamber will rise. There they collide and form a hot. In April. The warning lights switch off. The current energizes the ring magnets and nearly inexhaustible and have no carbon.

Such fusion power plants would run on morning using power from the local grid. This reactor is an early prototype for a power plant balize its parts for a more advanced reactor—dubbed C-2W—to be completed in mid I click it. The system stant. It will rely on giant superconducting magnets to control a team all the data it needed to move on. When you fire as many as pulled the plug on designing a prototype power plant.

Two years ago Livermore Just another shot at fusion. They also would zap to come. One example is the million kilometers an hour. Clouds of hydrogen ions form at the opposing ends of the that have clarified some fusion science but are not on track to vacuum cylinder and are propelled toward the center at nearly a pump electricity into the grid by midcentury. Sitting in the control room W. A power plant room had dropped a wrench onto the concrete floor.

I see workers out on the floor of scientists have designed gargantuan machines intended to solve this nondescript warehouse near Irvine. The plants would charges up banks of beefy capacitors. ITER will make no electricity. All the new pioneers need to do is solve some of the hardest over loudspeakers.

The backers are placing high-risk. That typically disruptive electric currents and magnetic fields. The tremes: Equally important. In this design. Frustrated senators voted 90—8 to cut off U. ITER aims for a low plasma density. Congress was. Most of the newcomers are searching for sweeter spots that lie in the less explored middle ground.

NIF and ITER are at opposite ends of a spectrum of plausible designs that spans a huge range of plasma densities and energy- confinement times a measure of how long heat stays inside the plasma. Forewarned by the glacial progress of the giants. Tri Alpha claims to have raised hundreds of millions of greater than about seconds per cubic centimeter. That pleases their investors.

Fission reactors. A big opportunity. But after a subsequent though guarded vote of confidence by the U. A get the candle lit. Another fast-moving group is ITER. Two atomic nuclei. Department of Energy. As of May. As a rule of thumb. To deliver. Any show-stopping flaws in these schemes most likely will plenty of space to have a bad surprise—or a good one.

Full operation will not come until at the earliest. In a power reactor. But the tests plasma. The fusion converts the missing mass into energy. Just three scale reactor that powers itself as well as the grid. The blobs remained stable and hot for five milliseconds. The designs shown here are for commercial-style reactors. Neutral beam injector 8 total Beams run along tube.

Laberge describes the stability problem. They have essentially solved tall. With each beat. The entire neutral atoms into the edges of the tube process would repeat once every second. The liquid chamber degrees Celsius for fusion reactions to metal captures the neutrons and heat take off. A brief. Eight injectors shoot beams of released by the fusion. If all goes well. But the Sandia system is. The team is trying to improve the sides.

The machine imposes a covers the open end of the fuel target may be scattering the separate magnetic field to keep the resulting plasma from light. Laberge argues. It has in experiments thus far. The thin window that ionizes the fuel as it starts to implode.

Sandia researchers calculate that it might be. That is more than 20 times for late Daniel Sinars. But if But competition could change that sentiment.

Half a continent away in New Mexico. According to Slutz. Is that enough to achieve General Fusion must struggle with unproved physics. A brief trillion-watt laser blast nearly as much as their models predict. For a squirting out the ends of the cylinder. But a laser may simply be the wrong tool for the job.

It is an elegant solution on a whiteboard, but no one has ever built such a system. And Laberge worries that as shock waves from the pistons pass through the lead-lithium mixture, some of the metal could spray into the plasma, squelching the fusion. The start-ups Currently that race in the U. Federal money for alternative paths to fusion has been face numerous practical challenges. Scientists Maybe, maybe not. Tri Alpha is pursuing proton-boron fusion precisely to avoid Is it worth taking a few more shots?

Plasma Physics: The Fusion Upstarts. But that technology does not yet exist. We once believed that the continents were fixed on the surface of Earth; now we know they move. We thought margarine was healthier than butter and that hormone-replacement therapy was the right treatment for vast numbers of postmenopausal women; now we know better.

But while scientists do not know everything, there is plenty they. And especially during this political season, it is dispiriting to see how many people—including political candidates—bizarrely reject some of the most basic, evidence-based truths that underlie modern science.

Psychological research has shown that being confronted with that mounting evidence can actually harden the positions of the truth deniers, so we do not pretend that the essays that follow will fix the problem. Nevertheless, we feel it is our duty to point out that some things actually are true, even in the constantly growing and evolving world of science. Because of a convergence of evidence from many lines of inquiry. Darwin came to this conclusion: Not only are the dates consistent.

It is not as if one scientist finds that a fossil hominin is 1. If new species are created naturally—not supernatu- rally—what place. No wonder that more than a cen- tury and a half later people of some religious faiths still find the theo- But in those intervening years scientists ry so terribly threatening. Nobody knows where this have never been shown to be dangerous. For example: The ages are given in estimates. And of course. Dobzhansky famously noted. The consistency of dating techniques also gives us confidence that the theory is true.

Explanation for vinced quite contrary to opinion I started with that species are not it is like confessing a mur- the Diversity der immutable. Trilobites and mammals are separated by many millions of years. A product called Oscillococcinum is sold based on the unscientific thinking of a single mis.

They consult two books. That means Muscovy duck the heart and liver. The el Hahnemann. What are you afraid of? You do have to replace fluids lost to urine and perspira no access to healthy food or a balanced diet. If any of that makes sense to you. It is active ingredient. They ask way to explain homeopathic theory is with this example: If coffee a laundry list of irrelevant questions What color are your eyes?

What keeps you awake. Any chemis- and Its Kindred Delusions. It is inconsistent with our basic knowledge of physics. All that remains is the quack. We have learned plenty since then. The cabal would also have to fake all the data from past climates that tells us there is no magic mechanism clouds or otherwise that will save us from the well-established warming effects of carbon dioxide acting in concert with water vapor.

Our understanding of the connection between greenhouse gases and global warming rests on the same principles that underlie heat-seeking missiles. Some of my favorites: Berlin wall. Likewise the carbon isotope and car- bon budget data that prove that the carbon dioxide accumulating in the atmosphere really does come from deforestation and burning fossil fuels.

If it is a conspiracy. Global warming is a problem. Homeopathy was bunk in Earth is not flat. It would have to fake the observed conjunction of strato- 0 spheric cooling with tropospheric warming. Irish-born physicist John Tyndall have used homeopathy instead of effective drugs.

Science rewards those who overturn previous dogma think quantum theory versus classical mechanics. People have died. I wish they radiation emitted back into space. As Edzard Ernst. It adds up to an awful lot of stuff to fake and makes faking the moon landing look like a piece of cake.

It would take quite a conspiracy to fake all that. Energy is conserved. And so on and so forth. People temporary Gustav Kirchhoff. You know it. By now There were many later developments in the 20th century. The Conspiracy Theories ed that it works no better than placebos.

Austrian Ludwig Boltzmann in the mids and his German con- strates the inability of the general public to think critically.

At the time. As a consequence. Animal tests But despite a handful of suspicious-looking studies. If the disorder is genetic. For the most part. Frederick Banting and Charles Best discovered insulin. It is nice to be able to point a finger at an evil force causing autism. Another possibility is that the notion that vaccines cause autism is comforting—certainly far more comforting than studies that have shown a genetic basis.

Until a clear cause and cure for autism emerge. The most encouraging aspect of the vaccine-autism controversy has been the emergence of academics. If autism is caused by events occurring out- side the womb. Criminal activity does not increase during the full moon. There are several plausible rea- sons why they feel this way. Conspiracy theorists argue that the only reason studies have shown that vaccines do not cause autism is that a vast international con- spiracy is hiding the truth.

Although only a small group of parents hold this belief. And everyone loves a bogeyman.

American 2015 pdf august scientific

Since then. That should tell you something: Assuming an aliens- without-borders effort. Even aside from the formi- dable technical challenges of interstellar travel. If aliens have been here weekly radio program. Aurum Press. Seth Mnookin. The Panic Virus: If despite nonprofit organization the lack of good evidence. I think the United Nations would notice.

Most of these can be explained as aircraft. Unless the extraterrestrials come from a very close star system. Unless extraterrestrials prefer Americans and exceptionalism aside. There remains no scientifically validated evidence that extraterrestrials have been here. The He also co-hosts a Roswell incident was nearly 70 years ago. Many people believe the latter. The History of a Modern Myth. Global Weirdness.

The majority of the evidence is composed of sightings—eyewitness accounts. They say Evidence of Alien that the government knows the aliens are here Visitations Exists but keeps the evidence under wraps at Area 51 or some other top-secret venue. Viking Adult. Why are they here now? Big Picture Science. The pyramids. Climate Central. The killer whale findings raise ques- emergence of new species. Whatever the motivation behind it. His research focuses on the mechanisms that create.

If so. The sun has burned off most of the morning mist. Exactly why the creatures engage in this scraping behavior. Despite their name. Plumper and Kaikash gently scrape their bodies against the small. British Columbia. Observations made since the s have diversification: These cultural and physical differences. J ust offshore from the pebble beaches of Bere Point on Malcolm Island. I watch from the boat as three killer whale brothers named Cracroft. That is. University of London.

Physical traits. In the favored scenario. Soon they will leave to hunt for salmon or look for mates. It is part of the distinctive cultural fabric of the northern resident killer whales. The brothers have already spent the better part of an hour here absorbed in this activity.

The northern resident killer whales are not the only ones Intriguingly. Mounting evidence indicates that cul. Documented examples specialize in hunting Antarctic minke whales.

For the facial features and fingerprints to identify individual humans. Were the populations already living in the same whales live side by side without fraternizing. One type. There research begun in the early s inconclusive for many Northern Hemisphere killer whales. Bigg and his colleagues. Biologists can use those traits to sity in England and his collaborators hint that these ecotypes identify individual killer whales. Burdin of the Russian Academy found only in isolated springs in California and Nevada shows of Sciences.

For its part humans. Current evidence is mostly the Northeast Pacific. Andrew sary for speciation to occur. Yet scientists have now shown that in various marine the killer whales. Resident ent environmental conditions. If this separation persists long enough. Deecke of the University of Cumbria in England.

Ford and graphical barrier of some kind—perhaps a mountain range. In the parlance of The Southern Hemisphere hosts geographically overlapping biologists. B Type 1 Preferred prey: They also differ in their physical features. These separate groups. Their cultural traditions probably differ depending on their preferred prey. The whales choose mates that share their customs rather than foreigners from other eco- types.

Yet studies show that in var- ious regions distinct forms. Culture appears to keep the ecotypes apart. Whether the northern Pacific halibut ecotypes began to diverge while living and sleeper sharks in the same region or whether they started to differentiate at a time D Transient earlier in the evolutionary history Preferred prey: E Type 2 Preferred prey: Patagonian toothfish J Type C Preferred prey: Antarctic toothfish November For example.

Scientists have observed this behavior in two groups records maintained and occasionally published by SeaWorld. In May of this year. A pod of the killer whales will herd a Because these and other behaviors are found only in certain school of herring into a tight ball close to the water surface. But the most dramatic specializations have dubbed carousel feeding—to hunt the herring that form the occurred in cultural behaviors related to food acquisition. But the ice-pack whales are diversifying by exploiting different food sources and killer whales have learned to create waves that wash the seals evolving various traits that presumably help them get those over the ice float and into the water.

Some of these distinguishing features are physical. Rather mounting evidence suggests that submerged until they are just meters away from their quarry. What is keeping them separate now? Breeding the beach. In Antarctica. G-clan and R-clan for the tions that live side by side.

Do other is. These discrete sounds exhibit geographical variation like. Although all sequently evade capture. That have diversified. The challenges the ecotypes face. Then individual so suggests that culture is keeping these ecotypes apart.

Fish-eating killer have also played a role in driving speciation among those early whales do not have the same problem. January Not only do the pulsed calls and whistles differ thropologists thought that most selective pressures that shaped among killer whales from different geographical regions.

Killer lations were during all phases of their diversification. Might culture the time they swim and hunt in stealth mode. There is no evidence to suggest that killer whale ecotypes? Some preliminary studies hint that the killer whales use these signals in any way that really resembles oceans around Africa might.

With the advent of and ecotype variation. April Rather the southern Asia come to mind. But they also often vary among social modern tools for studying genomes. The drug is illegal in the U. Photographs ScientificAmerican. The windows of your bed- room disappear into blackness. This scene bleeds into a darker one of demons. You are Shea Prueger. Thunderclouds cover the bedroom ceiling. Clinic op- and other treatments.

You cov- er your eyes. You cannot wake up—you cannot move your body. In the U. The year-old used to live in New York spread. Renegade Science. Today she is recall. So for two days in erators claim that a dose can curb addictive behavior.

The walls around you bend and twist. Narcotics Anonymous wide. The increase in needle what no other recovery treatment could do. She stayed clean ed remedy for an exploding problem.. An audience somewhere is clapping. Nothing worked. Sweats drips from your forehead. You want to get away. You have trouble breathing. In diction with a psychoactive drug called ibogaine.. After all adverse events. Around that time the late Howard Lotsof. Lex Kogan. Many seek help but do so in vain.

During treatment patients often suffer from car. From to a French pharmaceutical compa- works on many neural pathways at the same time. The stimu- panies. Many of from addictions to alcohol. It is illegal to use ibogaine as medicine in damage. Because withdrawal symptoms. Prueger is now chief administrator ing one in every treatments. About 80 per. Buoyed by these ideas. Word spread. Some animal studies of ibogaine and addiction came out times death.

That is why heroin addict. Published medical reports tie ibogaine to 19 in the late s. Not if it there is a toxic part. Animal studies suggest that of Envision Recovery. The overseas clinics began to open. In small amounts of around eight milligrams. During the previous two days. Schen- five years. Kogan says. That could indi- here and ready. Mallek swallowed the pill. Carefully monitoring heart health will help spot arrhythmias in case treat- ment is needed. Schen- an electrolyte solution to keep his body hydrated while he fasted berg reports that he conducted phone interviews and corrobo- on fruit and water.

Operators create mystical rituals cliff in a suburban neighborhood. When I interviewed Mallek. It is a manipulation. His study. An IV line was tied to his right arm. After a patient ingests ibogaine. Brown says he and his colleagues ence behind them. He had tried to get sober suffering and the pain of human beings and offer magical solu- dozens of times already. John J. Gretchen G. Some letters demonstrated that there are those who prefer to draw a sharply defined line between science and medicine, culture and politics—an impossible luxury when scientific knowledge is applied to ameliorating human ills.

Robert L. Teeter e-mailed: He is truly a hero of our times. The article described how an airplane wing produces lift thus: A better explanation of lift is: Thus, the wing exerts a downward force to accelerate this mass of air downward New- Harry Ison Bellingham, Wash. Imagine if the U. And yet in India, religious leaders became part of the solution.

How sad that we have not made life better for our own sex workers because of belief systems infected with pride. It is impossible to simulate a quantum computer efficiently on a conventional classical computer.

The simulation would require a vast supply of hardware to run algorithms in parallel, or it would take an extremely long time. Numerous readers wrote to correct a common but faulty explanation of how an airplane wing creates lift, noting that it has somehow persisted for years, even in textbooks. It also remarked below exerts more force on the wing that blocking the cutting of the prothan the faster air above, thereby lifting the plane. Rather preventing the clipping of LexA might undermine the tack, not its shape.

As for the topevolution of drug resistance in other side curvature of many wings, some microbes. Rehydration therapy saved this infant ditional lift. Others pointed out that from rotavirus-caused diarrhea. It has a high signal-to-noise ratio.

Ruiz, Jr. For a vetting of Shoreview, Minn.

Magazine Scientific American November | Electromagnetic Radiation | General Relativity

Without the lines, the both the Newtonian and Bernoullian explapuzzle has two solutions. Collins, is it visit that same site for extra puzzles and sopossible to simulate a quantum comput- lutions to the grids in the article. In Ask the Experts, Stephen M. Glass indicated that two rota- in theory? The John J. For a more in-depth explabeen shown to be highly effective in Madison, Wis.

This force also produces drag. The neutrino has been found. Frederick Reines and Clyde L. Cowan, Jr. The discovery of Neptune was a crowning achievement of classical physics: The neutrino is a similar achievement of modern physics, and its discovery is a vindication of the law of the conservation of energy.

As regards the new aeroplane which Messrs. Thus may be explained the persistency with which mythology and folk lore allude to pygmy people. At his own expense he sent out three expeditions. Two of them came to grief on the coast of South America, and the third was abandoned after cruising along the coast of Chile and Peru for several years in search of the treasure.

Within the case is a bell and spring hammer, the latter connected with a fob chain. The supposition is, that the thief will pull the chain in order to obtain the prize. But instead of getting the watch, the watch gets him. The pull sounds the alarm bell, the owner of the watch grabs the rogue, and the policeman conducts him to limbo.

But all that bon-offset programs are the latest rage. At partying had a downside — pollution. One least a dozen companies offer the promise to million soccer tourists consumed a lot of en- mitigate greenhouse gas emissions from acergy. A consortium Voluntary offset programs, however, are not including FIFA, the international soccer fed- regulated, so consumers cannot be sure that eration, and the German football associa- they are investing in environmentally sound tion DFB donated 1.

But governments are starting to pay heed to offsets. Europe established a cap-and-trade system last year that limits carbon dioxide emissions from about 50 percent of industry to reach its emissions goals as dictated by the Kyoto Protocol. As the trading market evolves, some environmentalists think that voluntary offset programs could join existing cap-and-trade market schemes to cut emissions even more substantially. That system suffered a setback in May after governments realized that they had set emissions limits too high.

The European Union is discussing how to tighten the scheme. Under the Regional Greenhouse Gas Initiative, Northeast and mid-Atlantic states plan to implement a market-based cap-and-trade program for all greenhouse gases emitted from power plants in the area. In California, a pending bill would cap greenhouse gas emissions from all industries in the state. The fermenting mass generates gas, which fuels stoves and replaces kerosene. Two other sustainable energy projects will take place in South Africa.

One will capture off-gas at a sewage treatment facility and burn it to supply electricity to Sebokeng, a township near Johannesburg. World Cup organizers could have planted trees — as has been done by previous sporting events, such as the Super Bowl— or invested in other projects on home turf. But planting has been criticized because trees take years of growth to suck up an equivalent amount of released carbon. Currently, voluntary activities do not generate tradable emission credits.

But imagine if they did. Next year, however, the high-energy frontier will move to Europe, where the even more powerful Large Hadron Collider will begin operations near Geneva.

Fermilab intends to shut down the Tevatron by The high-energy protons crash into beryllium targets, producing pions that spit out neutrinos as they decay.

Astrophysicists speculate that an unknown substance called dark energy has sped up the expansion over the past few billion years. Interestingly, the energy density needed to drive the current acceleration is roughly comparable to the estimated energy density of neutrinos.

Rob Fardon, Ann E. Fortunately, similar inters to a massive detector in the abandoned vestigations in Japan may complement the Soudan Iron Mine in northern Minnesota.

To increase their chances of The long journey gives the particles more success, Fermilab engineers are tweaking time to oscillate. This past March, MINOS their accelerators to maximize the power of scientists announced that only about half of the MINOS beam, which in turn raises the the expected muon neutrinos arrived at the number of neutrino interactions in the deSoudan detector, suggesting that the remain- tector.

The warranty did not cover oceanographic expeditions. Even J. Craig Venter, famous for his role in decoding the human genome, had frozen his microbial samples from the Sargasso Sea for sequencing back on shore. His results showed that the surface water in the balmy sea around Bermuda teems with genetic material. The biologists from Connecticut wanted to go deeper into the ocean— and go beyond microbes — to test for diversity among the animals at the base of the food web.

Working with a sequencer at sea would give them the best results. The researchers are part of the Census of Marine Life, an international network of marine scientists that began a mission in to identify every living creature in the ocean by Brown, Wiebe, the chief scientist, and his team used the net device to scour the Sargasso Sea.

Lashed down with a bungee cord in an air-conditioned room sat a brand-new, kilogram DNA sequencer. Zooplankton are w w w. Some individuals attract and sting prey; others propel the colony. The genes of this and all marine creatures may be sequenced by Whatever happens to zooplankton in the ocean has an immediate impact on the rest of the marine food web.

Change in pressure is not a problem for most of these grazers, which can descend hundreds of meters deep during the day.

At night they rise back up near the surface to feed, treading carefully near the thermocline, the distinct boundary between the deeper, colder water and the warmer surface water. A change in temperature from near freezing to bathtub-water warm can kill the temperature-sensitive creatures. But just how much of an impact it will have is unknown. This expedition changed and DNA break down. Most zooplank- that. By the time they returned to port on started at the surface and continued collecting throughout the water col- April 30, the scientists had catalogued animals and genetically bar-coded umn at every 1, meters of depth.

The expedition was unique in hav- of them. By the Census of ing taxonomists working over the mi- Marine Life scientists expect to have croscopes side by side with the molecu- bar-coded all 6, known species of lar biologists preparing the species for zooplankton and potentially that many sequencing. Maybe in spurts or maybe all at once, a fury of volcanism paved over nearly the entire surface.

To fathom why a planet would have done such a thing to itself, researchers need to know its inner torment. On Earth, such waves make themselves felt in various ways, ranging from radio interference created as they ripple through the ionosphere to the infrasound that some scientists think animals perceive during quakes.

It goes the other way, too: The dense Venusian atmosphere, usually a hindrance for observers, is a boon for aeroseismology. At a given altitude, the acoustic amplitude of a venusquake is times that of a comparable earthquake. Garcia says quakes might also generate the equivalent of tsunamis which are buoyancy-driven rather than pressure-driven waves.

His team estimates that a magnitude 6 quake, occurring at a depth of 30 kilometers, should cause the air pressure and density to oscillate by as much as 10 percent. It would raise the temperature at an altitude of kilometers by 10 degrees Celsius over an area kilometers across.

The heat pulse, lasting several minutes, is well within the means of the Venus Express spectrometer to detect— if it can be teased out from other atmospheric processes. Even the mere detection of a quake would be a breakthrough. To be sure, probing internal structure with the resolution of Earth seismology would require multiple seismometers on the ground, each refrigerated to survive the degree C temperature. The detection of quakes by VEx might shake loose support for a proposal by Stofan and her colleagues in the early s to do just that.

Only then might scientists come to learn why Venus is the goddess not of love but of tragedy. In May the Environmental Protection Agency proposed its continued sale, despite considerable evidence suggesting it is carcinogenic and harmful to the brain and nervous system, especially in children. On several occasions, the agency has come close to banning the pesticide — used in no-pest strips as well as in agriculture — but has always backed away.

They are to nerve agents than the human nervous sysnot entirely safe, either. One better alternative is boric acid, tem. The idea was that small amounts of especially when used in bait traps, these agents would be lethal to insects and which draw bugs and keep the harmless to people.

Fortunately, Questions about their safety arose in the the best ways to control insects s. The EPA considered a ban on 13 pesin the home do not require any pesticides, just good ticides in , including DDVP, but took housekeeping: The EPA missed that deadline.

The EPA again failed to act. The EPA has acted on many of them, but it is unlikely to meet its deadline for completing the pesticide review. But that is unlikely to limit human exposure, insists David E. The dispute is most likely headed to court. Paul Raeburn writes about science, policy and the environment from New York City. He some scholars, this ancient art represents compared these data with measurements the handiwork of shamans; others detect taken from children, teenagers and traces of initiation rites or trancelike states.

The groups A new interpretation offers a more prosaic are comparable, he reasoned, because both explanation for cave art: Statistically, the cave handprints match ing and sex. During the late Paleolithic era, 10, to up with modern children aged 10 to 16, 50, years ago, humans roamed a vast Guthrie reports in his book, The Nature of steppe covering modern Europe, Asia and Paleolithic Art, published earlier this year. North America. Guthrie estimates the sex ratio of the handprints as largely male, by three or four to one.

He argues that the subject matter of much Paleolithic art is consistent with its being created by adolescent boys, who would have been preoccupied with hunting and mating. As magical totems, perhaps part of hunting or evidence of its down-to-earth origins, he fertility rituals performed by shamans. Dale Guthrie, a paleobiologist emeritus at could still have played a role in some images, the University of Alaska—Fairbanks.

Dale Guthrie of the University of Alaska—Fairbanks. But that is not to say that they had a monopoly on artistic expression. The constant environment of a cave tends to preserve its contents, Guthrie notes, so those who ventured inside are disproportionately represented.

Jewelry, pottery, clothing and soft artifacts would have degraded more readily. It can be injected, snorted and eaten, but smoking is the most popular method. Smoking and injection provide the most stimulation. In the U. In , 1. Methamphetamine Use, Abuse, and Dependence: By the Northeast, the upper South, Texas, and comparison, cocaine binges rarely last more East Central states.

The meth problem grew out of addiction tin follows the epidemic closely. She believes to over-the-counter remedies available since that larger quantities of the drug are becomthe s for the treatment of asthma, nar- ing available in the East as organized gangs colepsy and other ailments.

Furthermore, amine, could also be used for staying awake she notes that these gangs are now selling and suppressing appetite, a boon to truck a purer and hence more potent form of drivers, students and people wanting to the drug. Meth users are probably getting sicker. In their wake, found that the number of meth users during many others followed: SAMHSA found, howephedrine or pseudoephedrine; the last are ever, that the proportion of these users medications available without prescription. That translates into , peomethamphetamine; Mexican gangs bring ple who are at particular risk of violence into the country most of the remainder.

They fabricated a touch sensitivity. Future touch sensors for robots based on this work will most likely rely not on light signals but rather on electrical impulses, researcher Ravi Saraf explains. For a few million years, the North Pole felt downright Floridian thanks to the presence of greenhouse gases released by some unknown geologic process. The warmth as recorded by the core data is 10 degrees Celsius higher than climate models had predicted.

Virtually all these chestnuts were killed within 50 years by a fungus introduced to the U. He notes that the chestnut-killing fungus may not have thrived on the dry, rocky mountaintop where this stand dwells. The American Chestnut Foundation announced May 19 it would breed the trees with blight-resistant Chinese chestnuts in the hopes of eventually developing a hardier, mostly American hybrid.

Marine biologists had noticed that in this typically social crustacean, sickly looking lobsters, infected with a lethal and contagious virus called PaV1, usually become isolated from the pack. To determine if the avoidance is purposeful, scientists set up two adjacent dens in a tank of seawater, tied either a sick or healthy lobster in one den and then introduced a second lobster.

If the second creature was already infected, it bunked with its sick or healthy tank-mate equally often. But healthy lobsters were one fourth as likely to share dens with infected lobsters than with healthy ones — even before the sickies became contagious — probably because of chemical signals.

A double-blind study, however, shows that a three-day treatment is just as effective. Though abundant in the centrosomes, few to no copies of these RNAs were found elsewhere in the cell, and their sequences were not seen in any genome database. Relatively little is known about the inner workings of centrosomes even after a century of study, and the investigators suggest their discovery could explain centrosome evolution and function.

One device consists of layers of gallium arsenide and aluminum arsenide that emit and partially trap sound vibrations in the solid phonons oscillating in the terahertz range. Physicists describe this so-called saser, for sound laser, in the June 2 Physical Review Letters. The system generates multidirectional ultrasound and might aid in studying so-called random lasers that likewise produce scattered, coherent light, co-designer Richard Weaver of the University of Illinois informed the Acoustical Society of America on June 8.

Fig trees may have marked the beginning of agriculture 11, years ago. Now, in a step toward using stem cells in cardiac repair, they have found where they lurk, based on mouse studies: Storms are similar bucket.

As they dialed up the speed to a few in principle to a semistationary bucket, spins per second, the vortex adopted a trefoil which may explain structured hurricane shape, then became square, pentagonal and eyes, and the underlying principle might aphexagonal. The sluggish outer layer of water ply to bathtub drains, too, Bohr says.

Water adopts trefoil, square and pentagonal shapes depending on the rotational speed. But much of physics is counterintuitive, as is the case in many other disciplines, and before the rise of modern science we had only our folk intuitions to guide us. Folk psychology compelled us to search for the homunculus in the brain— a ghost in the machine — a mind somehow disconnected from the brain.

Folk economics caused us to disdain excessive wealth, label usury a sin and mistrust the invisible hand of the market.

The reason folk science so often gets it wrong is that we evolved in an environment radically different from the one in which we now live. Our senses are geared for perceiving objects of middling size — between, say, ants and mountains — not bacteria, molecules and atoms on one end of the scale and stars and galaxies on the other end.

We live a scant three score and 10 years, far too short a time to witness evolution, continental drift or long-term environmental changes. Causal inference in folk science is equally untrustworthy. We correctly surmise designed objects, such as stone tools, to be the product of an intelligent designer and thus naturally assume that all functional objects, such as eyes, must have also been intelligently designed.

We lived in small bands of roaming hunter-gatherers that accumulated little wealth and had no experience of free markets and economic growth. Folk science leads us to trust anecdotes as data, such as illnesses being cured by assorted nostrums based solely on single-case examples.

Equally powerful are anecdotes involving preternatural beings, compelling us to make causal inferences linking these nonmaterial entities to all manner of material events, illness being the most personal. Because people often recover from sickness naturally, whatever was done just before recovery receives the credit, prayer being the most common. The April issue of the American Heart Journal published a comprehensive study directed by Harvard Medical School cardiologist Herbert Benson on the effects of intercessory prayer on the health and recovery of patients undergoing coronary bypass surgery.

The 1, patients were divided into three groups, two of which were prayed for by members of three religious congregations. Prayers began the night before the surgery and continued daily for two weeks after. Half the prayer recipients were told that they were being prayed for, whereas the other half were told that they might or might not receive prayers. Case closed. But for us to discriminate true causal inferences from false, real science trumps folk science.

Although the administration of George W. Bush has often stated its commitment to the spread of democracy, partly to combat the risks of terror, it relies excessively on military approaches and threats rather than strategic aid. Consider Liberia, just emerging from a prolonged civil war, and Haiti, which has suffered decades of intense political instability.

Both nations have recently elected new democratic governments, but both face continuing possibilities of internal violence and disorder. When the public thinks that a newly elected national government will succeed, local leaders throw their support behind it.

Individuals and companies become much more likely to pay their taxes, because they assume that the government will have the police power to enforce the tax laws. A virtuous circle is created. Rising tax revenues strengthen not only the budget but also political authority and enable key investments — in police, teachers, roads, electricity— that promote public order and economic development.

When the public believes that a government will fail, the same process runs in reverse. Pessimism splinters political forces. Tax payments and budget revenues wane. The currency weakens. Banks face a withdrawal of deposits and the risk of banking panics. Disaster feeds more pessimism.

By attending to the most urgent needs of these fragile states, U. To an informed and empathetic observer, the necessary actions will usually be clear. Both Liberia and Haiti lack electricity service, even in their capital cities.

Both suffer from pervasive infectious diseases that are controllable but largely uncontrolled. But if each impoverished farm family is given a bag of fertilizer and a tin of high-yield seeds, a good harvest with ample food output can be promoted within a single growing season. Electric power can be restored quickly in key regions. And safe water outlets, including boreholes and protected natural springs, can be constructed by the thousands within a year.

Far too often, however, the U. Rather than giving practical help, the rich countries and international agencies send an endless stream of consultants to design projects that arrive too late, if ever.

They ignore emergency appeals for food aid. Pessimism breeds pessimism. Eventually the government falls, and the nascent democracy is often extinguished. By thinking through the underlying ecological challenges facing a country— drought, poor crops, disease, physical isolation— and raising the lot of the average household through quick-disbursing and well-targeted assistance, U.

Like many physicists, Connes hopes that the Higgs particle will show up in detectors. The Higgs is the still missing crowning piece of the so-called Standard Model— the theoretical framework that describes subatomic particles and their interactions. In commutative algebra, the product is independent of the order of the factors: But some operations are noncommutative.

Take, for example, a stunt plane that can aggressively roll rotate over the longitudinal axis and pitch rotate over an axis parallel to the wings. Assume a pilot receives radio instructions to roll over 90 degrees and then to pitch over 90 degrees toward the underside of the plane. But if the order is inverted, the plane will take a nosedive. Operations with Cartesian coordinates in space are commutative, but rotations over three dimensions are not.

Because of the Heisenberg uncertainty principle, one cannot measure both quantities simultaneously. As a consequence, position times momentum does not equal momentum times position. Hence, the quantum phase space is noncommutative.

Moreover, introducing such noncommutativity into an ordinary space — say, by making the x and the y coordinates noncommutative — produces a space that has noncommutative geometry. Through such analyses, Connes discovered the peculiar properties of his new geometry, properties that corresponded to the principles of quantum theory.

On a day plagued by introducing a mathematical technique called renormalization. Like a caged lion, the year-old Connes walks corresponded to reality. Outside, police sirens scream amid student protes- portunity to explore the space in which physics lives. The linkage gave renormalization a mathematically rigel. The relation between renormalization and noncommutaBut the spacetime used in general relativity, also based on tive geometry serves as a starting point to unite relativity and electrodynamics, was left unchanged.

Connes proposed some- quantum mechanics and thereby fully describe gravity. He has already shown, with physicist Carlo Rovelli is that of spacetime as a noncommutative space that can be of the University of Marseille, that time can emerge naturally viewed as consisting of two layers of a continuum, like the from the noncommutativity of the observable quantities of two sides of a piece of paper.

The space between the two sides gravity. Time can be compared with a property such as temof the paper is an extra discrete noncontinuous , noncom- perature, which needs atoms to exist, Rovelli explains.

What about string theory? The discrete part creates the Higgs, whereas the continuum parts generate the gauge bosons, such as the W and the quantum world? Connes contends that his approach, looking for the mathematics behind the physical phenomena, and Z particles, which mediate the weak force.

2015 scientific american pdf august

Connes has become convinced that physics calculations is fundamentally different from that of string theorists. Although the Standard Model which still is a long way to go to reach the Planck scale, which proved phenomenally successful, it quickly hit an obstacle: That is not quite halfway. Physicists, in- But to Connes, the glass undoubtedly appears half full. Starting around , workers will cultivate expertise technology in the s.

Yet it is maturing rapidly. By , nents into three-dimensional circuits and whole devices. Descriptions of nanotech typically characterclude molecular nanosystems — heterogeneous ize it purely in terms of the minute size of the physnetworks in which molecules and supramolecular structures serve as distinct devices.

The proteins ical features with which it is concerned — assemblies between the size of an atom and about molecular inside cells work together this way, but whereas biological diameters.

But at this scale, rearranging the atoms wider range of environments and should be much faster. Comand molecules leads to new properties. Medical applications might be as ambitious as new and the adjustable behavior of collectives.

Thus, nanotechnol- types of genetic therapies and antiaging treatments. Nanotech does, however, , involves the development of passive nanostructures: Helping the public to perceive nanobers in new composites or carbon nanotube wires in ultra- tech soberly in a big picture that retains human values and quality of life will also be essential for this powerful new disminiaturized electronics.

The second stage, which began in , focuses on active cipline to live up to its astonishing potential. New drug-delivery particles Mihail C.

Roco is senior adviser for nanotechnology to could release therapeutic molecules in the body only after they the National Science Foundation and a key architect reached their targeted diseased tissues. Electronic compo- of the National Nanotechnology Initiative. ROCO Rearranging atoms leads to new properties.

The craters are named after the Argonauts of Greek mythology: After all, he reasoned, in the entire 20th century, astronomers had come across only a few. Sheppard more optimistically predicted twice as many, given the increased sensitivity of modern astronomical facilities. Sheppard is now a richer man. Since that night, our team has discovered 62 moons around the giant planets, with more in the pipeline.

Other groups have found an additional But even astronomers generally adopt the popular usage. Adding to the challenge, they are distributed over a much larger region of space. Scanning such a vast area for moons demands the newest, largest digital detectors and the analysis of up to gigabytes of data a night [see box on page 46].

Our own Hawaii Moon Survey focused initially on Jupiter, whose proximity allows us to probe small moons that would be too faint to detect around the other, more distant giant planets. Their long, looping, slanted orbits indicate that they did not form in situ but instead in paths encircling the sun.

In essence, they are asteroids or comets that the planets somehow captured. The moons might have come from the Kuiper belt beyond Neptune or from regions closer in. Their capture may have involved collisions or other interactions in a younger, more densely populated solar system. All four giant planets, irrespective of mass, turn out to have similar irregular moon systems.

The bodies occupy a wide range of sizes, with smaller ones being much more abundant. The orbits of these moons are some of the most complicated in the solar system.

Because they roam so far from their host planet, they are tugged by both planetary and solar gravity, and their orbits precess rapidly— that is, the long axis of the ellipse representing the orbit rotates. Odder still, most of the irregulars have retrograde orbits, which means they each trundle around their host planet in a direction opposite to the sense of the rotation of the planet.

In contrast, regular moons have prograde orbits. Regular moons share this motion because, astronomers think, they coalesced from disks around their respective planets. So the contrary behavior of the irregular moons is a sign of a different origin. These bodies are not well explained by standard models, and a wave of fresh theoretical work is under way.

It seems that they are products of a long-gone epoch when the gravitational tug of the newly formed planets scattered — or snatched— small bodies from their original orbits. Studying them promises to illuminate the early stages in the development of the solar system.

The full extent of the system of moons around Saturn was barely known until recent years. The satellites fall into two broad categories: Some revolve in the same direction as Saturn rotates red ; others go the opposite way green. Similar systems surround the other giant planets far left. These diagrams show a sampling of the total number of moons. The otherwise modest effects of solar gravity accumulate over time, destabilizing the orbit; the ellipse elongates to such an extent that the moon either collides with the planet or one of its larger moons or breaks out of the Hill sphere and falls into the gravitational clutches of the w w w.

Prograde orbits are more vulnerable than retrograde ones. If irregular moons were originally equally likely to be either prograde or retrograde, this resonance could explain why most moons are now retrograde. Another resonance, known as the Kozai resonance, couples the tilt and shape of the orbit.

Moons that are hauled into inclined orbits wind up on highly stretched ellipses, again leading potentially to their ejection or destruction.

That may be why observers have found no moons with inclinations between 50 and degrees. In short, the irregular moons we see today appear to be the survivors of gravitational interactions that cleared out many of their brethren. Still other features of the orbits require processes beyond those of gravity.

If so, many of the irregular moons we see today are the second generation — one step removed from the original population. Beyond learning something about the orbits of irregular moons, astronomers have made some progress in discerning other properties. Most of the moons are so faint that they have been able to uncover very little about their composition.

Color is a proxy for composition, so this discovery implies a likeness in makeup — further supporting the idea that group members are fragments of a larger, bygone parent body. The two irregular moons of Neptune seen by the Voyager 2 space probe, Nereid and Triton, also have icy surfaces. The ices hint that these objects formed relatively far from the sun, like comets.

The irregular moons of Jupiter are pitchblack and appear to be devoid of ice, probably because they are closer to the sun and too warm for ice to be stable. Astronomers have proposed three capture mechanisms. For all three, the initial stage is the formation of asteroid-size bodies called planetesimals. Many agglomerate to form the rocky cores of the giant planets. The leftovers are vulnerable to being captured. Understanding how that happened is not easy. In the complex interplay of solar and planetary gravity, asteroids and comets are routinely pulled into shortlived orbits around the giant planets.

Jewitt traces his interest in astronomy to age seven, when he was astonished by a spectacular meteor shower visible against the sodium-lit night skies of industrial north London. Sheppard, his former graduate student, recently became a Hubble postdoctoral fellow in the department of terrestrial magnetism at the Carnegie Institution of Washington. Kleyna grew up on a farm in Maine, enjoys incomprehensible art-house cinema and is now a Parrent postdoctoral fellow at the University of Hawaii, where he mainly studies dark matter in dwarf galaxies.

The leaves enter the vortex, swirl around for perhaps a few dozen times and then are blown out in an unpredictable way. Had it not met an untimely death, the comet would have been ejected back into heliocentric orbit within a few hundred years.

Astronomers know of several objects that survived temporary capture by Jupiter and returned to orbiting the sun. Planetesimals passing through this atmosphere lose energy to friction and can be captured. Its gravity rapidly strengthens, snatching nearby planetesimals that happen to fall within its expanded gravitational domain, or Hill sphere. Two planetesimals passing near the planet almost collide.

One loses energy and falls into orbit white. The other gains energy and escapes red. But for a body to be permanently captured from heliocentric orbit into a bound, stable orbit around a planet, it must lose some of its initial energy.

Essentially the body has to be slowed down to prevent it from escaping again. Moon capture, then, must have occurred long ago, at a time when the solar system had different properties.

In the s theorists proposed three possible mechanisms, all functioning during or soon after the epoch of planet formation. Pollack and Joseph A. Tauber of Cornell University, w w w. Jupiter and Saturn, quite unlike Earth and other terrestrial planets, are composed primarily of hydrogen and helium.

Most probably, they formed when a core of rock and ice, of roughly 10 Earth-masses, pulled in vast quantities of gas from the primordial disk surrounding the young sun.

Before settling into their modern, relatively compact forms, the planets may have passed through a transient, distended phase, during which their atmospheres extended hundreds of times farther than they do now. In true Goldilocks style, a passing asteroid or comet would have met one of three distinct fates, depending on its size.

If it was too small, it burned up in the bloated atmosphere, like a meteor. If it was too large, it plowed through unimpeded and continued in orbit about the sun.

If it was just right, it slowed down and was captured. This process is a natural version of the aerobraking procedure that many planetary probes have used to enter orbit. One problem with the gas-drag model is that it does not explain the presence of irregular satellites around Uranus and Neptune.

They are equipped with digital detectors of more than million pixels each. The central problem is to distinguish objects in the solar system from more distant stars and galaxies. Observers use two methods. We compare three images of the same area, spaced some time apart.

During that time, Earth moves partway around the sun, changing our vantage point and causing bodies to appear to shift position; the closer the body, the more it appears to move.

The second method involves a velocity measurement. In the summed image, background stars appear as streaks and the irregular moons as bright dots. This mechanism of capture was first expounded by Thomas A. Like gas drag, however, this mechanism has trouble accounting for the moons around Uranus and Neptune, neither of which underwent a runaway growth in mass. Most models indicate that these planets grew slowly by accumulating asteroid- and comet-size bodies, perhaps taking tens or hundreds of millions of years to reach their presentday masses.

The other objects here are background stars. Thought to be about two kilometers across, the moon has an orbit that stretches 31 million kilometers away from the giant planet. An alternative model for forming Uranus and Neptune, proposed by Alan Boss of the Carnegie Institution of Washington, is that they started out as massive as Jupiter and Saturn and were whittled down by ionizing radiation from nearby massive stars. The irregular moons are even harder to understand in this model, because a shrinking planet would tend to lose moons rather than grabbing them.

In both the gas-drag and pull-down models, the irregular moons were acquired early in solar system history, probably before Earth had reached a recognizable state. Because of their greater distance from the sun and the consequently lower density of material in the outer regions of the circumsolar disk, their cores took a longer time to reach the critical mass needed to precipitate gaseous collapse. Before that happened, the solar nebula had largely dissipated, and so Uranus and Neptune never had extended atmospheres, like those of Jupiter and Saturn.

How can gas drag operate when there is not much gas? They suggested that collisions between two bodies in the Hill sphere of a planet could dissipate enough energy to allow one of them to be captured. This idea, called three-body capture, received relatively little attention in the 35 intervening years, perhaps because such collisions are exceedingly rare now.

Yet newer work shows that no collision is needed. The three bodies need only interact gravitationally. If they exchange energy, one can gain energy at the expense of the others. The process is a scaled-up version of the gravitational slingshot effect that space mission planners use to boost deep space probes.

This past May, Craig Agnor of the University of California, Santa Cruz, and Doug Hamilton of the University of Maryland suggested another form of three-body capture in which a binary object is sheared apart by the gravity of a planet, leading one component to be ejected and the other pulled into orbit.

The process works for both gas giants and ice giants. These types of interactions would have been most probable near the end of the planet formation epoch, after the Hill spheres had grown to their present proportions but before the leftover debris of planet formation had been cleared out. Threebody capture might be able to account for why each planet has roughly the same number of irregular moons: Even if three-body interactions explain how the irregular moons were captured, where did they come from to begin with?

Researchers have suggested two distinct possibilities. The moons could be asteroids and comets that had w w w. Most of their cohorts were incorporated into the bodies of the planets or catapulted out of the solar system. Another possibility emerges from a recent model in which the solar system remained choked with debris until some million years after the planets formed. Strong gravitational interactions between Jupiter and Saturn then set up oscillations that shook the entire system.

Billions of asteroids and comets were scattered as the major planets lurched into their present, more stable orbits. A tiny fraction of the scattered bodies could have been captured.

In this scenario, proposed last year by K. Luu and David C. Spectral measurements should one day be able to test these two hypotheses. If they have similar compositions, that would argue for the second hypothesis, in which the moons all formed together and then dispersed. Recent work suggests that it and a partner orbited the sun in mutual embrace, until Neptune sundered them and claimed Triton as its own. Exploration of the irregular moon systems is ongoing.

Two things are already evident: The modern solar system simply offers no suitable mechanism through which moons could be captured. Second, the similarities among the irregular moon populations of all four outer planets suggest that they arose by three-body interactions, the only known mechanism that is about as effective for Neptune as it is for Jupiter.

Like skid marks on a road after a car crash, the irregular moons swooping around the giant planets provide us with tantalizing clues about past events that we could never have witnessed directly.

Kavelaars et al. Discovery of Five Irregular Moons of Neptune. Matthew J. Holman et al. Photometry of Irregular Satellites of Uranus and Neptune. Tommy Grav, Matthew J. Holman and Wesley C. Fraser in Astrophysical Journal, Vol. Available online at arxiv. Cassini Imaging Science: Initial Results on Phoebe and Iapetus. Porco et al. Craig B. Agnor and Douglas P. Hamilton in Nature, Vol. Hawaii Irregular Satellite Survey Web site: AUGUS T Disabled genes, molecular relics scattered across the human genomic landscape, have a story of their own to tell.

The bones of long-dead genes — known as pseudogenes— litter our chromosomes. It is already clear that a whole genome is less like a static library of information than an active computer operating system for a living thing. As products of the processes by which genomes remodel and update themselves, pseudogenes are providing new insights into those dynamics, as well as hints about their own, possibly ongoing, role in our genome. If errors in a copy destroy its ability to function as a gene, dogenes during the late s, when however, it becomes a pseudogene instead right.

The alignment shown here of incapable of giving rise to a protein. Cellular sequence that looked like a globin gene machinery reads the DNA alphabet of nucleotide a partial sequence for a human gene RPL21 but could not possibly give rise to a proagainst one of its pseudogene copies bases abbreviated A, C, G, T in three-base tein.

Even single-base mutations in codons in pseudogenes. The human genome is made up Nonsynonymous mutation of more than three billion pairs of nucleotides, the building blocks of DNA molecules. Yet less than 2 percent of our genomic DNA directly encodes proteins.

With ongoing annotation of the hu- many of them and why, if they are really Perhaps a third is noncoding sequences man genome sequence, our research useless, they have been retained in our within genes, called introns. The re- group, along with others in Europe and genome for so long. A small much of it is effectively genomic dark discovered. Humans have only an esti- fraction of pseudogenes are believed to matter whose function is still largely a mated 21, protein-coding genes, so have once been functional genes that mystery.

But most randomly scattered like rusted car parts parts. Their sheer prevalence has raised pseudogenes are disabled duplicates of on the landscape — and in surprising many questions, including how they working genes. They may have been came into existence, why there are so dead on arrival, having suffered lethal numbers. Normally, the mRNA is destined for translation into a protein — but sometimes it can instead be reverse-transcribed back into DNA form and inserted in the genome.

A splicing process next cuts introns out of the raw transcript and joins exonic sequences to produce an edited messenger RNA mRNA version of the gene. Pseudogenes can be born in two ways, each of which yields a distinctive facsimile of the original parent gene. Just before dividing, a cell duplicates its entire genome, and during that process, an extra copy of a gene can be inserted into the chromosomes in a new location.

Alternatively, a new version of a gene can also be created through reverse transcription: Known as retrotransposition, this phenomenon can occur because of the activity of another type of transposable genetic actor, known as a long interspersed nuclear element, or LINE, that behaves like a genomic virus. These two processes, duplication and retrotransposition, are major forces that remodel genomes over the course of evolutionary time, generating new variation in organisms.

They are the means by which genomes grow and diversify, because many replicated genes remain active. But if the gene copy contains disabling typos or is missing pieces of the original, such as the promoter, it will become a pseudogene.

Pseudo genes made from mRNA lack introns and are described as processed pseudogenes. Although the overall distribution of most pseudogenes across human chromosomes seems completely random, certain kinds of genes are more likely to give rise to pseudogenes. Geneticists organize functional genes into families based on their similarity to one another in both sequence and purpose.

Only about a quarter of these family groups are associated with a pseudogene, and some families have spun off an inordinate number of copies. In one extreme case, a single ribosomal protein gene known as RPL21 has spawned more than pseudogene copies. Those responsible for basic cellular housekeeping functions, such as the genes in the ribosomal protein family, are abundantly expressed, providing more opportunities to create processed pseudogenes.

Because pseudogenes have been accreting this way in our genomes for so long, some are relics of genes eliminated during the course of evolution, and no functional version exists today.

Consequently, intergenic regions can be seen as vast molecular fossil beds offering a silent record of events in our evolutionary past. Family Histories t h e p r i nc i pl e s of natural selection appear to extend to individual genes, strongly constraining mutations in the sequences of functional genes. Gulo makes an enzyme that is the last element in a biochemical pathway for synthesizing vitamin C.

Most mammals possess the active gene, but the primate lineage seems to have lost it more than 40 million years ago. When the Gulo gene became a pseudogene, primates became dependent on food sources of vitamin C to avoid scurvy.

Scientists can use this tendency to derive a kind of molecular clock from the nucleotide changes in pseudogenes and use it to study the overall dynamics and evolution of the genome. Tracking the evolutionary path of genes and pseudogenes helps molecular biologists to uncover instances of gene birth and death just as the study of mineral fossils tells paleontologists about the creation and extinction of species. About 8, of our pseudogenes are processed; the rest include duplicated pseudogenes and other nonprocessed subcategories.

RPL21 orange are scattered across the human chromosomal landscape. Overall distribution of pseudogenes in the human genome appears to be completely random, although some local genome regions tend to contain more pseudogenes.

Those DNA regions may be analogous to certain geochemical environments that better Differences in pseudogenes offer hints about diverse life histories. Lancet and his colleagues found in Analysis of the mouse genome, for studies of apes, monkeys and other dis- example, has shown that 99 percent of tant primate cousins that the greatest human genes have a corresponding verloss of olfactory receptor genes — that is, sion in the mouse.

Although the human the greatest increase in OR pseudo- and mouse lineages diverged some 75 genes — occurred in ape and monkey lin- million years ago, nearly all of the human eages that evolved the ability to see color genome can be lined up against equivain three wavelengths of visible light. The lent regions, known as syntenic blocks, link may suggest that a sensory trade-off in the mouse genome. Yet despite this took place over time in the primate lin- similarity in functional genes and overeage when better eyesight made an acute all genome structure, just a small fraction sense of smell less critical.

Using the rate of sequence decay ceptor repertoire. Many dead-on-arrival relative to the parent genes to determine pseudogene copies are an immediate by- their age, it is also clear that many pseuproduct of this process. But the subse- dogenes in the human and mouse gequent death of additional duplicates, nomes have arisen at different times.

Consequently, differences pseudogenes in each of the lineages. The number of pseudogenes in different genomes varies greatly, more so than genes, and it is not readily predictable, because it is neither strictly proportional to the size of a genome nor to the total number of genes.

One of the largest known gene families in mammals, for example, consists of more than 1, different genes encoding olfactory receptors, the cell-surface proteins that confer our sense of smell. Detailed analyses of olfactory receptor OR genes and pseudogenes by Doron Lancet and Yoav Gilad of the Weizmann Institute of Science in Rehovot, Israel, show that humans have lost a large number of functional olfactory receptor genes during evolution, and we now have fewer than of them in our genome.

For comparison, versions of about human olfactory receptor pseudogenes are still functional genes in the genomes of rats and mice. This difference is not surprising given that most animals depend more for their survival on the sense of smell than humans do.

In fact, humans have considerably more olfactory receptor pseudogenes than chimpanzees do, indicating that we lost many of those functional genes after our split from the ape lineage. Zheng, after completing his Ph. But Gerstein and Zheng were intrigued by the enormous data analysis challenges posed by the sequencing of the human genome and chose to start scanning and sifting the regions of DNA between genes. These disablements cannot be tolerated by true genes and are thus typical manifestations of pseudogenes.

More subtly, the theory of neutral evolution introduced by mathematical biologist Motoo Kimura in the s holds that nonfunctional DNA sequences can change freely, without the constraint of natural selection. Thus, individual nucleotide mutations can be divided into two types: Large-scale pseudogenization is most often seen among genes that, like the olfactory receptor family, are responsible for responses to the environment.

Such pseudogenes may therefore be under evolutionary constraint, which implies that they might have some function after all.

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